Selank

 Selank is a synthetic peptide derived from tuftsin, a naturally occurring immunomodulatory peptide. It is known for its anxiolytic (anti-anxiety), nootropic (cognitive-enhancing), and immunomodulatory effects. Selank has been extensively studied for its potential in treating anxiety disorders, depression, and cognitive impairments, as well as its ability to enhance immune function.

Research has demonstrated Selank's efficacy in reducing anxiety and improving mood in animal models and human clinical trials. It works by modulating the levels of neurotransmitters, such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), which are involved in regulating mood and anxiety. Selank also increases the expression of brain-derived neurotrophic factor (BDNF), a protein that supports neuronal survival, plasticity, and cognitive function. These properties make Selank a promising alternative to traditional anxiolytics, such as benzodiazepines, which are associated with side effects like sedation and dependence.

In addition to its anxiolytic effects, Selank has been shown to enhance cognitive function and memory. It improves attention, learning, and information processing in animal models and human studies. Selank's nootropic effects are thought to be mediated by its ability to modulate the hypothalamic-pituitary-adrenal (HPA) axis, reduce oxidative stress, and promote neurogenesis.

Selank also exhibits immunomodulatory properties, enhancing the body's ability to fight infections and regulate immune responses. It increases the production of cytokines, such as IFN-γ and IL-2, which are critical for antiviral and antitumor immunity. Selank has been investigated as a potential treatment for viral infections, including influenza and herpes simplex virus (HSV), as well as for its ability to enhance the efficacy of vaccines.

Despite its therapeutic potential, Selank's mechanisms of action are not fully understood, and its long-term safety in humans remains under investigation. Ongoing research aims to optimize dosing regimens and explore its potential applications in psychiatry, neurology, and immunology.